Treating ATTR Amyloidosis Now a Possibility as Novel Immunotherapy Enters Clinical Trial

Our researchers at the Chakrabartty lab have identified a novel immunotherapeutic drug target in the transthyretin (TTR) protein. This is a common transport protein that carries thyroxine through the blood and cerebrospinal fluid. If monomeric TTR is ever found misfolded it will not form its native homo-tetramer correctly (originally in the blood this protein native structure is comprised of four …

pyGemPick – Python Based, Open Source Automatic Batch Immunogold Particle Detection

pyGemPick is the first python-based module built for the automatic processing and detection of nanno gold particles on immunogold stained transmission electron microscopy images. The project came to life under undergraduate researcher, Joseph Marsilla’s vision. Project features highlight the engineering of a novel high-contrast filtering technique that uses a two-fold binary screening approach that is selectivity for the nanogold particles …